Reduction of carboplatin induced emesis by ondansetron
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Effects of Ondansetron on Xylazine Induced Emesis in Cats
Objective- Vomiting frequently is reported after xylazine administration in cats. This study evaluates prophylactic antiemetic efficacy of ondansetron in cats sedated with xylazine HCl. Design- Experimental study. Animals- Six healthy adult cats from both genders were selected for the study. Interventions- Intramuscular injection of normal saline was administered an hour before intr...
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To determine the contribution of metoclopramide to the efficacy of ondansetron in control of cisplatin-induced emesis, ondansetron was compared with ondansetron plus metoclopramide for antiemetic efficacy in a randomized double-blind trial. Enrolled 66 patients were treated with cisplatin(60mg/m2) in combination with etoposide, flourouracil, or vinblastine, and randomized to receive either onda...
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Topal A. , M. Kaya, N. Gül: Ondansetron and Granisetron in the Prophylaxis of Nausea and Emesis Induced by Cisplatin in Dogs. Acta Vet. Brno 2005, 74: 111-116. In the present study, the effects of 5-HT3 receptor antagonist granisetron and ondansetron on the acute phase of cisplatin-induced nausea and emesis were analyzed in dogs. Fifteen healty dogs were used in this study. Cisplatin was admini...
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OBJECTIVE To determine the contribution of dexamethasone to the efficacy of the 5-hydroxytryptamine antagonist ondansetron in control of cisplatin induced nausea and vomiting. DESIGN Randomised double blind crossover study. SETTING Two cancer centres in teaching hospitals, one in the United Kingdom and the other in Germany. SUBJECTS 100 patients (53 men and 47 women) new to cisplatin chem...
متن کاملEfficacy & tolerability of ondansetron compared to metoclopramide in dose dependent cisplatin-induced delayed emesis.
BACKGROUND & OBJECTIVES Delayed emesis with cisplatin is a significant problem, which is often poorly controlled with conventional antiemetics. There is a relative paucity of data on the control of delayed emesis and rather inconsistent results have been reported. The present study aimed to compare the efficacy and tolerability of ondansetron versus metoclopramide in dose related grades of cisp...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1991
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1991.206